|
|
|
|
|
Click Here to return To Results
|
|
|
|
The combination of measurements of regional cerebral blood flow(rCBF)and blood velocity in the middle cerebral arteries(MCA)by transcranial doppler sonography was used to investigate cerebrovascular involvement in migraine.Ten migraine patients with unilateral headache were studied during an attack and when they had been free of attacks for 5 days(non- attack).On both occasions they were given an intravenous infusion of sumatriptan(2 mg),a 5-HT1-like receptor agonist,which relieved the symptoms within 30 min without affecting rCBF.The MCA velocity was normal on both sides of the non-attack day and on the unaffected side during the attack.However,during the attack the MCA velocity on the headache side was significantly lower than that on the non-headache side(45 vs 61 cm/s:mean difference 16.3[95%confidence interval 10.3-22.3];p=0.02).The MCA velocity on the headache side returned to normal after treatment with sumatriptan and recovery.Since rCBF in the MCA supply territory was unaffected,the lower velocity can be explained only by dilatation of the MCA.The mean MCA diameter increase was estimated to be 20%.Thus,headache was associated with intracranial large arterial dilatation on the headache side. Sumatriptan predominantly had effects on the distended artery,which suggests that the 5-HT receptor system has a role in the pathogenesis of migraine. |
|
(click to filter results - removes previous filter)
cerebral blood flow
doppler,transcranial
headache,treatment of
migraine
migraine,pathogenesis
migraine,treatment of
regional cerebral blood flow
serotonin
serotonin agonist
sumatriptan
treatment of neurologic disorder
|
Click Here to return To Results
|
|